As I rummaged through my fridge, I stumbled upon the ultimate solution to a hectic weeknight dinner: Meat Lovers Pizza Casserole. This dish elegantly marries the heartiness of a meat-loaded pizza with the cozy warmth of a classic casserole. Not only is it a delightful treat for both friends and family, but it also boasts the perks of being freezer-friendly and quick to prepare—perfect for those nights when time is of the essence. With a gooey layer of melted cheese and a golden crust, this casserole will transport you back to your favorite pizza parlor in a single bite. Are you ready to turn your kitchen into a cozy pizzeria?

Why is this Meat Lovers Pizza Casserole a must-try?
Comforting, Hearty Flavors: This casserole brings together all the classic pizza flavors you adore, loaded with meats and ooey-gooey cheese that will make your taste buds dance.
Quick & Easy: Ready in just 35 minutes, it’s a solution for those busy weeknights when you crave something delicious yet straightforward.
Freezer-Friendly: Prep a batch ahead of time! You can easily freeze leftovers for a quick meal later, making it perfect for meal prep.
Family-Friendly Appeal: Kids will love the pizza-like taste, ensuring that even the pickiest eaters are satisfied.
Pair it with a side of garlic bread or a fresh Caesar salad for a complete meal experience!
Meat Lovers Pizza Casserole Ingredients
For the Casserole
- Lean Ground Beef – Provides hearty protein; substitute with ground turkey for a lighter option.
- Pork Sausage – Adds richness and flavor; consider Italian chicken sausage for a leaner choice.
- Chopped Pepperoni – Brings that classic pizza taste; use turkey pepperoni for a lighter alternative.
- All-Purpose Flour – Serves as a thickener in the sauce; can be omitted or swapped for gluten-free flour.
- Italian Seasoning (4 tsp) – Infuses authentic Italian flavors; fresh herbs can be used but adjust the quantity accordingly.
- Tomato Basil Pasta Sauce (26 oz) – Forms the savory sauce layer; marinara or spicy arrabbiata works well for different profiles.
- Shredded Mozzarella Cheese (2 cups) – Provides that melty, cheesy goodness characteristic of pizza; pre-shredded saves time!
- Refrigerated Pizza Crust Dough (13.8 oz) – Acts as the base of the casserole; biscuit dough can create a fluffier texture.
- Olive Oil (1 Tbsp) – Enhances flavor and ensures a golden crust; melted butter is a delicious alternative.
- Grated Parmesan Cheese (3 Tbsp) – Adds a savory topping; optional for a lighter finish.
This Meat Lovers Pizza Casserole is not only packed with bold flavors but also embodies the comfort of home-cooked meals, making it an absolute favorite for family dinners!
Step‑by‑Step Instructions for Meat Lovers Pizza Casserole
Step 1: Preheat and Prepare
Begin by preheating your oven to 425°F (220°C). While the oven warms up, take a 9×13-inch baking dish and spray it generously with cooking spray. This will ensure your Meat Lovers Pizza Casserole comes out easily once baked and has a lovely golden crust.
Step 2: Cook the Meats
In a large skillet over medium-high heat, add the lean ground beef and pork sausage. Cook until they are beautifully browned, taking about 6-8 minutes, while stirring occasionally to break up the meat. Once browned, drain any excess fat to avoid a greasy casserole, ensuring a satisfying meal.
Step 3: Mix in Flavors
Stir in the chopped pepperoni, flour, and 3 teaspoons of Italian seasoning with the cooked meat. Mix well to ensure all the ingredients are evenly combined, creating a flavorful base for your casserole. Allow this mixture to cook for another 2-3 minutes for the flavors to meld.
Step 4: Add the Sauce
Pour in the tomato basil pasta sauce, stirring continuously until it comes to a gentle boil. This process should take about 2 minutes. Once bubbling, remove the skillet from heat, as your rich sauce is now ready to complement the other layers of your Meat Lovers Pizza Casserole.
Step 5: Assemble the Casserole
Spoon the hearty meat mixture into the prepared baking dish, spreading it out evenly. Top it with 1½ cups of shredded mozzarella cheese, allowing the cheesy goodness to melt and bind the flavors beautifully as it bakes.
Step 6: Layer the Dough
Unroll the refrigerated pizza crust dough over the cheese, gently stretching it to cover the surface. Drizzle the dough with olive oil, brushing it evenly, and sprinkle the remaining Italian seasoning, along with an additional ½ cup of mozzarella and the grated Parmesan cheese for that extra touch of flavor.
Step 7: Bake to Perfection
Place the casserole in the preheated oven and bake for 20-25 minutes. Look for a golden-brown crust on top, which indicates it’s perfectly cooked. As the aroma fills your kitchen, your Meat Lovers Pizza Casserole will be transforming into a mouthwatering dish.
Step 8: Cool and Serve
After baking, take the casserole out of the oven and let it cool for a few minutes. This resting time will help it set, making slicing easier when you serve. Now, it’s time to enjoy your delicious home-cooked Meat Lovers Pizza Casserole with family and friends!

What to Serve with Meat Lovers Pizza Casserole?
A cozy casserole like this transforms dinner into a comforting feast for everyone around the table.
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Garlic Bread: The crunchy, buttery goodness of garlic bread complements the casserole’s cheesy richness, perfect for soaking up excess sauce.
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Caesar Salad: This classic salad provides a refreshing crunch with romaine, Parmesan, and tangy dressing that balances the savory flavors of the casserole.
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Roasted Vegetables: A medley of roasted carrots, bell peppers, and zucchini brings a sweet contrast and a pop of color to your meal, enhancing both flavor and nutrition.
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Stuffed Mushrooms: These savory bites filled with cheese and herbs pack a flavorful punch, offering an elegant yet simple appetizer that pairs well with the casserole.
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Coleslaw: A zesty coleslaw adds a refreshing crunch, cutting through the richness of the casserole while providing a delightful textural contrast.
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Red Wine: A glass of medium-bodied red wine, like Chianti or Merlot, elevates the meal and beautifully complements the hearty flavors of the Meat Lovers Pizza Casserole.
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Chocolate Chip Cookies: End the evening on a sweet note with warm chocolate chip cookies, a comforting tradition that everyone loves after a hearty dinner!
Expert Tips for the Best Meat Lovers Pizza Casserole
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Don’t Skimp on Draining: Drain the meat well after cooking to prevent a greasy casserole that can detract from the overall texture and flavor.
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Fresh Cheese Matters: For the best melty texture, opt for fresh mozzarella instead of pre-shredded. It melts beautifully and complements the casserole perfectly.
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Prebake for Crispiness: Consider prebaking the pizza crust for about 5 minutes before layering it on top; this helps achieve a satisfyingly crispy finish!
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Let It Rest: Allow the casserole to cool for a few minutes after baking. This will help it set up, making slicing easier and serving neater.
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Spice it Up: For a kick of heat, add crushed red pepper flakes or substitute with hot Italian sausage in your Meat Lovers Pizza Casserole.
How to Store and Freeze Meat Lovers Pizza Casserole
Fridge: Store leftovers in an airtight container for up to 4 days. Make sure to cool the casserole completely before sealing it to maintain freshness.
Freezer: Wrap tightly in plastic wrap or aluminum foil before freezing for up to 2 months. Thaw in the fridge overnight before reheating for optimal texture.
Reheating: For individual servings, microwave until heated through. If reheating the entire casserole, bake at 350°F for approximately 20-25 minutes, or until warmed throughout.
Make-Ahead: Prepare the Meat Lovers Pizza Casserole in advance and assemble it, covering tightly; then refrigerate until ready to bake.
Meat Lovers Pizza Casserole Variations
Feel free to get creative and personalize your casserole with these delightful twists that add flair and flavor!
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Extra Veggies: Boost nutrition with sliced mushrooms, diced bell peppers, or sautéed onions for added color and crunch.
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Bacon Boost: Crumble some cooked bacon into the meat mixture for an irresistible richness that’ll elevate every bite.
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Spicy Kick: For those who love heat, swap in spicy sausage or toss in jalapeños to ignite your taste buds!
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Gluten-Free Option: Use gluten-free flour and a gluten-free pizza crust to make this dish friendly for those with dietary needs.
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Herb Infusion: Switch basil for fresh oregano or thyme to refresh and lift the flavor profile to new heights!
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Cheese Variations: Try adding provolone or fontina cheese for a gourmet touch beyond the classic mozzarella.
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Pasta Addition: Mix in cooked pasta, like rotini or penne, to create a hearty pasta bake style casserole that’s even more filling.
If you’re searching for more delicious ideas, check out my recipes for Chicken Spaghetti Casserole or a fun twist with Honey Flatbread Pizza. The possibilities are endless—happy cooking!
Make Ahead Options
These Meat Lovers Pizza Casserole is a fantastic candidate for meal prep, saving you precious time during busy weeknights! You can prepare the meat mixture and assemble the casserole up to 24 hours in advance, simply refrigerating it in the baking dish covered with plastic wrap. For optimal freshness and flavor, store the unbaked casserole in the fridge and bake it straight from the cold for about 30-35 minutes. Alternatively, if you want to prep it for later enjoyment, wrap the assembled casserole tightly and freeze it for up to 2 months. When ready to serve, thaw it overnight in the refrigerator, and bake as instructed for a deliciously hearty meal the whole family will love!

Meat Lovers Pizza Casserole Recipe FAQs
How do I know if my ingredients are ripe or fresh?
Absolutely! For the meat, choose fresh ground beef and pork sausage with a bright color and no visible spoilage. When selecting pepperoni, opt for a vibrant red without dark spots. For the tomato sauce, check the expiration date to ensure freshness. A quick sniff test can also help—if it smells off, it’s best to toss it!
What’s the best way to store leftovers?
Very! Store any leftover Meat Lovers Pizza Casserole in an airtight container in the fridge for up to 4 days. Make sure the casserole is fully cooled before sealing it; this helps prevent moisture buildup which can lead to spoilage.
Can I freeze Meat Lovers Pizza Casserole?
Absolutely! To freeze, wrap the casserole tightly in plastic wrap or aluminum foil, and it will be good for up to 2 months. When you’re ready to enjoy it again, thaw it in the fridge overnight. Reheat in the oven at 350°F (175°C) for about 20-25 minutes, or until warmed through.
What should I do if my casserole seems too greasy?
If your Meat Lovers Pizza Casserole turns out greasy, there are a couple of things you can do for next time! Be sure to drain the cooked meats well before mixing them into the casserole. You can also consider using leaner cuts of meat or even substitute some of the sausage with veggies. Adding them will bring flavor without the extra grease!
Are there any dietary considerations for this recipe?
Very good question! For those with gluten sensitivities, you can use gluten-free flour and pizza dough to accommodate dietary needs. Furthermore, if anyone in your family has meat allergies, consider replacing the meats with plant-based alternatives, or incorporate more veggies for a delicious twist! Always check the label for any hidden allergens.
What are the optimal reheating instructions?
For the best flavor and texture, reheat individual servings in the microwave for 1-2 minutes or until warmed through. If you have the whole casserole, bake it at 350°F (175°C) for around 20-25 minutes. This method ensures maximum cheesiness and a delightful crust, just like when it was first baked!

Meat Lover Pizza Casserole: Comfort Food for Family Nights
Ingredients
Equipment
Method
- Preheat your oven to 425°F (220°C) and spray a 9x13-inch baking dish with cooking spray.
- In a large skillet over medium-high heat, cook the lean ground beef and pork sausage until browned, about 6-8 minutes. Drain excess fat.
- Stir in the chopped pepperoni, flour, and 3 tsp of Italian seasoning with the cooked meat. Cook for another 2-3 minutes.
- Add the tomato basil pasta sauce and stir until it comes to a gentle boil, about 2 minutes.
- Spread the meat mixture into the prepared baking dish and top with 1½ cups of shredded mozzarella cheese.
- Unroll the pizza crust dough over the cheese, drizzle with olive oil and sprinkle with remaining Italian seasoning, ½ cup of mozzarella, and Parmesan.
- Bake for 20-25 minutes until the crust is golden brown.
- Let the casserole cool for a few minutes before serving.

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