In a small bowl, combine softened cream cheese, granulated sugar, and vanilla extract. Beat until creamy and smooth, about 2-3 minutes.

In a large mixing bowl, whisk together melted unsalted butter and granulated sugar. Add eggs, vanilla extract, and milk, whisk until smooth.

In another bowl, whisk together all-purpose flour, baking powder, and salt. Gradually incorporate this dry mixture into the wet ingredients.

Gently fold in blueberries into the batter using a spatula.

Prepare a greased loaf pan, pour half of the batter, spoon half the cream cheese mixture, repeat layering.

Preheat your oven to 350°F (175°C) and bake for approximately 60 minutes. Check doneness with a toothpick.

Once baked, cool in the pan for about 10 minutes, then transfer to a wire rack to cool completely.